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Latent Space: The AI Engineer Podcast

Latent Space: The AI Engineer Podcast

The podcast by and for AI Engineers! In 2025, over 10 million readers and listeners came to Latent Space to hear about news, papers and interviews in Software 3.0. We cover Foundation Models changing every domain in Code Generation, Multimo…

71 transcripts 71 total episodes
71 transcripts
🔬“We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing
Latent Space: The AI Engineer Podcast
🔬“We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing
Aug 26, 2026 · 1h 23m
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Simulation: the new Scaling Law — Joon Sung Park, Simile AI
Latent Space: The AI Engineer Podcast
Simulation: the new Scaling Law — Joon Sung Park, Simile AI
Aug 21, 2026 · 1h 9m
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🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery
Latent Space: The AI Engineer Podcast
🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery
Aug 11, 2026 · 1h 35m
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The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten
Latent Space: The AI Engineer Podcast
The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten
Aug 03, 2026 · 1h 41m
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Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI
Latent Space: The AI Engineer Podcast
Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI
Jul 28, 2026 · 1h 9m
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Inside the Model Factory — Eiso Kant, Poolside AI
Latent Space: The AI Engineer Podcast
Inside the Model Factory — Eiso Kant, Poolside AI
Jul 23, 2026 · 1h 54m
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🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)
Latent Space: The AI Engineer Podcast
🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)
Jul 21, 2026 · 1h 29m
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🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences
Latent Space: The AI Engineer Podcast
🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences
Jul 16, 2026 · 1h 41m
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Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO
Latent Space: The AI Engineer Podcast
Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO
Jul 08, 2026 · 57m
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🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI
Latent Space: The AI Engineer Podcast
🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI
Jul 01, 2026 · 1h 48m
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Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks
Latent Space: The AI Engineer Podcast
Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks
Jun 24, 2026 · 1h 8m
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Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan
Latent Space: The AI Engineer Podcast
Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan
Jun 22, 2026 · 1h 6m
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The Professor of Outputmaxxing — Anjney Midha, AMP
Latent Space: The AI Engineer Podcast
The Professor of Outputmaxxing — Anjney Midha, AMP
Jun 18, 2026 · 59m
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🔬 The Self-Driving Lab — Joseph Krause, Radical AI
Latent Space: The AI Engineer Podcast
🔬 The Self-Driving Lab — Joseph Krause, Radical AI
Jun 17, 2026 · 1h 16m
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Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs
Latent Space: The AI Engineer Podcast
Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs
Jun 04, 2026 · 1h 15m
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🔬Scaling Past Informal AI - Carina Hong, Axiom Math
Latent Space: The AI Engineer Podcast
🔬Scaling Past Informal AI - Carina Hong, Axiom Math
Jun 03, 2026 · 1h 33m
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⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build
Latent Space: The AI Engineer Podcast
⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build
Jun 03, 2026 · 38m
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GitHub's plan for Agents — Kyle Daigle, GitHub
Latent Space: The AI Engineer Podcast
GitHub's plan for Agents — Kyle Daigle, GitHub
Jun 02, 2026 · 1h 23m
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Why Video Agent models are next — Ethan He, xAI Grok Imagine
Latent Space: The AI Engineer Podcast
Why Video Agent models are next — Ethan He, xAI Grok Imagine
Jun 01, 2026 · 1h 43m
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The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray
Latent Space: The AI Engineer Podcast
The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray
May 28, 2026 · 1h 8m
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🔬ESMFold2: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
Latent Space: The AI Engineer Podcast
🔬ESMFold2: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
May 27, 2026 · 1h 10m
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Giving Agents Computers — Ivan Burazin, Daytona
Latent Space: The AI Engineer Podcast
Giving Agents Computers — Ivan Burazin, Daytona
May 21, 2026 · 1h 10m
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Railway: The Agent-Native Cloud — Jake Cooper
Latent Space: The AI Engineer Podcast
Railway: The Agent-Native Cloud — Jake Cooper
May 20, 2026 · 1h 28m
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The Next War Is Already Here. The West Isn't Ready. — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion
Latent Space: The AI Engineer Podcast
The Next War Is Already Here. The West Isn't Ready. — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion
May 18, 2026 · 1h 59m
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AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge
Latent Space: The AI Engineer Podcast
AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge
May 14, 2026 · 1h 5m
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🔬Doing Vibe Physics — Alex Lupsasca, OpenAI
Latent Space: The AI Engineer Podcast
🔬Doing Vibe Physics — Alex Lupsasca, OpenAI
May 05, 2026 · 1h 31m
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Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition
Latent Space: The AI Engineer Podcast
Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition
Apr 27, 2026 · 1h 12m
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AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)
Latent Space: The AI Engineer Podcast
AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)
Apr 23, 2026 · 54m
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Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO
Latent Space: The AI Engineer Podcast
Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO
Apr 22, 2026 · 1h 12m
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🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik
Latent Space: The AI Engineer Podcast
🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik
Apr 20, 2026 · 1h 25m
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Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion
Latent Space: The AI Engineer Podcast
Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion
Apr 15, 2026 · 1h 17m
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Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony
Latent Space: The AI Engineer Podcast
Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony
Apr 07, 2026 · 1h 12m
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Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"
Latent Space: The AI Engineer Podcast
Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"
Apr 03, 2026 · 1h 16m
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Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun
Latent Space: The AI Engineer Podcast
Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun
Apr 02, 2026 · 1h 6m
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Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample
Latent Space: The AI Engineer Podcast
Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample
Mar 30, 2026 · 48m
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🔬Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik
Latent Space: The AI Engineer Podcast
🔬Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik
Mar 24, 2026 · 35m
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Dreamer: the Personal Agent OS — David Singleton
Latent Space: The AI Engineer Podcast
Dreamer: the Personal Agent OS — David Singleton
Mar 20, 2026 · 1h 3m
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Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop
Latent Space: The AI Engineer Podcast
Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop
Mar 17, 2026 · 1h 26m
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Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer
Latent Space: The AI Engineer Podcast
Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer
Mar 12, 2026 · 1h 0m
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NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo)
Latent Space: The AI Engineer Podcast
NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo)
Mar 10, 2026 · 1h 23m
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Cursor's Third Era: Cloud Agents
Latent Space: The AI Engineer Podcast
Cursor's Third Era: Cloud Agents
Mar 06, 2026 · 1h 6m
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Every Agent Needs a Box — Aaron Levie, Box
Latent Space: The AI Engineer Podcast
Every Agent Needs a Box — Aaron Levie, Box
Mar 05, 2026 · 1h 16m
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METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity
Latent Space: The AI Engineer Podcast
METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity
Feb 27, 2026 · 56m
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[LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka
Latent Space: The AI Engineer Podcast
[LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka
Feb 26, 2026 · 52m
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🔬Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI
Latent Space: The AI Engineer Podcast
🔬Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI
Feb 25, 2026 · 33m
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Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis
Latent Space: The AI Engineer Podcast
Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis
Feb 24, 2026 · 2h 4m
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⚡️The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data
Latent Space: The AI Engineer Podcast
⚡️The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data
Feb 23, 2026 · 26m
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Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z
Latent Space: The AI Engineer Podcast
Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z
Feb 19, 2026 · 55m
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Owning the AI Pareto Frontier — Jeff Dean
Latent Space: The AI Engineer Podcast
Owning the AI Pareto Frontier — Jeff Dean
Feb 12, 2026 · 1h 23m
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🔬Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery
Latent Space: The AI Engineer Podcast
🔬Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery
Feb 12, 2026 · 1h 21m
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The First Mechanistic Interpretability Frontier Lab — Myra Deng & Mark Bissell of Goodfire AI
Latent Space: The AI Engineer Podcast
The First Mechanistic Interpretability Frontier Lab — Myra Deng & Mark Bissell of Goodfire AI
Feb 06, 2026 · 1h 8m
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🔬 Automating Science: World Models, Scientific Taste, Agent Loops — Andrew White
Latent Space: The AI Engineer Podcast
🔬 Automating Science: World Models, Scientific Taste, Agent Loops — Andrew White
Jan 28, 2026 · 1h 13m
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Captaining IMO Gold, Deep Think, On-Policy RL, Feeling the AGI in Singapore — Yi Tay
Latent Space: The AI Engineer Podcast
Captaining IMO Gold, Deep Think, On-Policy RL, Feeling the AGI in Singapore — Yi Tay
Jan 23, 2026 · 1h 32m
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Brex’s AI Hail Mary — With CTO James Reggio
Latent Space: The AI Engineer Podcast
Brex’s AI Hail Mary — With CTO James Reggio
Jan 17, 2026 · 1h 13m
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Artificial Analysis: Independent LLM Evals as a Service — with George Cameron and Micah-Hill Smith
Latent Space: The AI Engineer Podcast
Artificial Analysis: Independent LLM Evals as a Service — with George Cameron and Micah-Hill Smith
Jan 08, 2026 · 1h 18m
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[State of Evals] LMArena's $1.7B Vision — Anastasios Angelopoulos, LMArena
Latent Space: The AI Engineer Podcast
[State of Evals] LMArena's $1.7B Vision — Anastasios Angelopoulos, LMArena
Jan 06, 2026 · 24m
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[NeurIPS Best Paper] 1000 Layer Networks for Self-Supervised RL — Kevin Wang et al, Princeton
Latent Space: The AI Engineer Podcast
[NeurIPS Best Paper] 1000 Layer Networks for Self-Supervised RL — Kevin Wang et al, Princeton
Jan 02, 2026 · 28m
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[State of Code Evals] After SWE-bench, Code Clash & SOTA Coding Benchmarks recap — John Yang
Latent Space: The AI Engineer Podcast
[State of Code Evals] After SWE-bench, Code Clash & SOTA Coding Benchmarks recap — John Yang
Dec 31, 2025 · 17m
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[State of Post-Training] From GPT-4.1 to 5.1: RLVR, Agent & Token Efficiency — Josh McGrath, OpenAI
Latent Space: The AI Engineer Podcast
[State of Post-Training] From GPT-4.1 to 5.1: RLVR, Agent & Token Efficiency — Josh McGrath, OpenAI
Dec 31, 2025 · 27m
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[State of RL/Reasoning] IMO/IOI Gold, OpenAI o3/GPT-5, and Cursor Composer — Ashvin Nair, Cursor
Latent Space: The AI Engineer Podcast
[State of RL/Reasoning] IMO/IOI Gold, OpenAI o3/GPT-5, and Cursor Composer — Ashvin Nair, Cursor
Dec 30, 2025 · 45m
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[State of AI Startups] Memory/Learning, RL Envs & DBT-Fivetran — Sarah Catanzaro, Amplify
Latent Space: The AI Engineer Podcast
[State of AI Startups] Memory/Learning, RL Envs & DBT-Fivetran — Sarah Catanzaro, Amplify
Dec 30, 2025 · 28m
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One Year of MCP — with David Soria Parra and AAIF leads from OpenAI, Goose, Linux Foundation
Latent Space: The AI Engineer Podcast
One Year of MCP — with David Soria Parra and AAIF leads from OpenAI, Goose, Linux Foundation
Dec 27, 2025 · 1h 39m
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Steve Yegge's Vibe Coding Manifesto: Why Claude Code Isn't It & What Comes After the IDE
Latent Space: The AI Engineer Podcast
Steve Yegge's Vibe Coding Manifesto: Why Claude Code Isn't It & What Comes After the IDE
Dec 26, 2025 · 37m
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⚡️GPT5-Codex-Max: Training Agents with Personality, Tools & Trust — Brian Fioca + Bill Chen, OpenAI
Latent Space: The AI Engineer Podcast
⚡️GPT5-Codex-Max: Training Agents with Personality, Tools & Trust — Brian Fioca + Bill Chen, OpenAI
Dec 26, 2025 · 27m
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SAM 3: The Eyes for AI — Nikhila & Pengchuan (Meta Superintelligence), ft. Joseph Nelson (Roboflow)
Latent Space: The AI Engineer Podcast
SAM 3: The Eyes for AI — Nikhila & Pengchuan (Meta Superintelligence), ft. Joseph Nelson (Roboflow)
Dec 18, 2025 · 1h 15m
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⚡️Jailbreaking AGI: Pliny the Liberator & John V on Red Teaming, BT6, and the Future of AI Security
Latent Space: The AI Engineer Podcast
⚡️Jailbreaking AGI: Pliny the Liberator & John V on Red Teaming, BT6, and the Future of AI Security
Dec 16, 2025 · 40m
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AI to AE's: Grit, Glean, and Kleiner Perkins' next Enterprise AI hit — Joubin Mirzadegan, Roadrunner
Latent Space: The AI Engineer Podcast
AI to AE's: Grit, Glean, and Kleiner Perkins' next Enterprise AI hit — Joubin Mirzadegan, Roadrunner
Dec 12, 2025 · 1h 9m
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The Future of Email: Superhuman CTO on Your Inbox As the Real AI Agent (Not ChatGPT) — Loïc Houssier
Latent Space: The AI Engineer Podcast
The Future of Email: Superhuman CTO on Your Inbox As the Real AI Agent (Not ChatGPT) — Loïc Houssier
Dec 11, 2025 · 1h 11m
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World Models & General Intuition: Khosla's largest bet since LLMs & OpenAI
Latent Space: The AI Engineer Podcast
World Models & General Intuition: Khosla's largest bet since LLMs & OpenAI
Dec 06, 2025 · 1h 4m
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After LLMs: Spatial Intelligence and World Models — Fei-Fei Li & Justin Johnson, World Labs
Latent Space: The AI Engineer Podcast
After LLMs: Spatial Intelligence and World Models — Fei-Fei Li & Justin Johnson, World Labs
Nov 25, 2025 · 1h 0m
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⚡️ 10x AI Engineers with $1m Salaries — Alex Lieberman & Arman Hezarkhani, Tenex
Latent Space: The AI Engineer Podcast
⚡️ 10x AI Engineers with $1m Salaries — Alex Lieberman & Arman Hezarkhani, Tenex
Nov 19, 2025 · 27m
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